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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The excitatory effect of oxytocin was enhanced by external magnesium, and the dose-response curve between oxytocin and relative … tiny muscle strips shifted to the left with increases in magnesium from 0 to 2.4 mM. Oxytocin potentiates spontaneous contractions by enhancing the … induced in 2.4-mM magnesium ….”
“These results suggest that magnesium might primarily potentiate the excitatory effect of oxytocin in electrical and mechanical activities of pregnant human myometrium at superficial sites of the plasma membrane, allowing the possibility of its intracellular action.”
Modification by Magnesium of the Excitatory Effect of Oxytocin in Electrical and Mechanical Activities of Pregnant Human Myometrium“Although responses to oxytocin were increased by magnesium , they were less potentiated than the responses to other peptides.”
“ Valyl oxytocin action on the other hand was potentiated by magnesium in all 4 cases studied.”
“In the absence of extracellular calcium, intracellular calcium release in response to oxytocin was inhibited by magnesium.”
“ Oxytocin produced cytosolic calcium oscillations and simultaneous phasic contractions; both were inhibited by magnesium.”
Cellular mechanisms underlying magnesium sulfate inhibition of phasic myometrial contractions.
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