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Last Updated: 2 years ago

Possible Interaction: Magnesium Oxide and Duloxetine

Research Papers that Mention the Interaction

However, the antidepressant-like effects of a duloxetine reagent were significantly attenuated by the co-administration of magnesium oxide.
In the in vitro experiment, the duloxetine concentration was significantly decreased by co-treatment with magnesium oxide.
In the in vivo experiment, the antidepressant-like effects of duloxetine were not affected by the combined oral administration of magnesium oxide and a duloxetine formulation although the serum duloxetine level was significantly decreased.
These results suggest that duloxetine and magnesium oxide directly interact and that such interactions affect the absorption and antidepressant-like effects of duloxetine.
Biological & pharmaceutical bulletin  •  2018  |  View Paper