“However, the antidepressant-like effects of a duloxetine reagent were significantly attenuated by the co-administration of magnesium oxide.”
“In the in vitro experiment, the duloxetine concentration was significantly decreased by co-treatment with magnesium oxide.”
“In the in vivo experiment, the antidepressant-like effects of duloxetine were not affected by the combined oral administration of magnesium oxide and a duloxetine formulation although the serum duloxetine level was significantly decreased.”
“These results suggest that duloxetine and magnesium oxide directly interact and that such interactions affect the absorption and antidepressant-like effects of duloxetine.”