Possible Interaction: Magnesium and Norepinephrine

“Mean daily excretion of noradrenaline and adrenaline was significantly diminished after magnesium.”

“These findings indicate that, except for differences due to the normally dilated state of the kidney, the effects …, magnesium, and potassium on renal vessels are similar to their effects on forelimb and coronary vessels, and that magnesium and probably potassium depress the sensitivity … and forelimb vascular muscle to levarterenol.”

“Moreover, the correlation between Mg level changes and blood epinephrine and norepinephrine levels were observed.”

“ Norepinephrine levels increased from 297.3 ± 20.9 pg/ml to a peak of 532.5 ± 30.1 pg/ml 2 minutes after intubation in the magnesium group.”

“Therefore we speculated that magnesium has inhibitory effect on sympathetic tone and we showed that magnesium inhibit norepinephrine release from peripheral sympathetic nerve endings.”

“Thus, Mg removal impairs inhibitory function of the endothelium against contraction induced by norepinephrine , without affecting endothelium-dependent relaxation in response to acetylcholine, in the rat femoral artery.”

“Fetal plasma concentrations of epinephrine, norepinephine , and vasopressin significantly increased from the prehypoxemic values both with magnesium and in controls.”

“However, in anesthetized rats, MS 250 mg.kg-1 ip lowered the hypertensive response to angiotensin amide and norepinephrine.”

“Since magnesium is known to be a physiological antagonist of calcium and to have … on the contraction of coronary vascular smooth muscle, we examined the importance of magnesium in modulating both the direct vasoconstrictor response … the NPY-induced inhibition of relaxation to noradrenaline , using ring preparations … circumflex coronary artery.”

“The presence of raised concentrations of magnesium (4.4 or 13.2 mM) in the tissue bath further depressed the prostaglandin F2 alpha and noradrenaline contractions in calcium-free medium.”