Possible Interaction: Magnesium and Nitric Oxide

“ Magnesium and vitamin B6 modulates the level of NO in the cell, both of which are deficient in migraineurs.”

“In addition, we demonstrate that high concentrations of magnesium did not modulate the levels of plasminogen activator inhibitor-1, but enhanced the synthesis of nitric oxide , in part through the up-regulation of endothelial nitric oxide synthase.”

“In addition, magnesium seems to alter NO synthesis (5).”

“When NO was added to Mg , PVR/SVR decreased significantly (0.31+/-0.06 to 0.16+/-0.02; p<0.05) but not when Mg was added to NO.”

“This neuroprotective property of magnesium might be mediated in part through the inhibition of NO production shortly after OGD.”

“These results suggest that extracellular magnesium exerts a direct inhibitory effect on the spontaneous release of EDRF and is apparently important for the expression of endothelium-dependent relaxation induced by acetylcholine and thrombin, but not calcium ionophore A23187, in canine coronary arteries.”

“Indeed, in bioassay cascade studies, magnesium removal from the medium used to perfuse intact artery or vein enhanced the formation and/or release of an endothelium-derived relaxing factor by calcium-dependent mechanisms.”

“The data suggest that vascular endothelium-derived nitric oxide is responsible for the calcium-dependent relaxation elicited by extracellular magnesium depletion.”

“Ca was found to stimulate, while Mg inhibits, the basal release of EDRF , such that a lowering of extracellular Mg (0-Mg) resulted in an "unmasking" of Ca-induced endothelium (EDRF)-dependent relaxation.”

“Zinc, iron and magnesium all decrease in response to NO˙ while cellular manganese increases significantly.”

“Through series of characterizations, it was found that Mg substitution at both A- and B-sites improves the specific surface area, Mn4+ content, reactivity of surface oxygen species, redox property and NO adsorption capacity of LaMnO3.”