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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Magnesium
drug:
Nifedipine
Research Papers that Mention the Interaction
“ Nifedipine blunted the pressor response to salt loading > 50% (delta diastolic BP [high-low salt vs placebo] = 5 +/- 2 vs 14 +/- 2 mmHg, P < 0.05) and reversed salt-induced ionic changes, lowering Cai and elevating Mgi and pHi.”
Intracellular ionic consequences of dietary salt loading in essential hypertension. Relation to blood pressure and effects of calcium channel blockade.“This reaction demonstrates that nifedipine can seriously potentiate the toxicity of magnesium.”
“The concomitant application of nifedipine resulted in a higher excretion of Ca, Mg and citrate when compared to the cholesterol group.”
Influence of nifedipine on stone formation and renal function in cholesterol-induced nephrolithiasis in rats.“We hypothesized that verapamil and nifedipine would potentiate the cardiac toxicity of magnesium in a dose-dependent manner.”
“However, magnesium depletion attenuates the blood pressure-lowering effect of nifedipine.”
“The excretion of magnesium and citrate, reduced by an atherogenous diet, could be raised significantly with the administration of nifedipine.”
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