Possible Interaction: Magnesium and Nicotine

“There is evidence that magnesium deficit is involved in addiction to various addictive substances (heroin, morphine, cocaine, nicotine , alcohol, caffeine, and others).”

“ Magnesium decreases the intensity of some drug-induced dependences (e.g. opiates, nicotine , cocaine, amphetamine, ethanol, etc.).”

“Therapeutic administration of magnesium decreases nicotine dependence and cocaine/amphetamine self-administration.”

“Calcium, barium, and magnesium , however, increased the potency of nicotine for desensitization induced by exposure to low, subactivating concentrations of nicotine.”

“5-Hydroxytryptamine and nicotine were about twice as sensitive to the blocking effect of magnesium than was acetylcholine or histamine.”

“Choline esters (acetylcholine, methacholine, propionylcholine and butyrylcholine), anticholinesterases (eserine and neostigmine), ganglionic stimulant agents nicotine and dimethylphenylpiperazinium) and polypeptides (angiotensin, eledoisin and bradykinin) acting from the serosal surface, antagonized the peristaltic block caused by magnesium added to the organ bath.”

“Noradrenaline (1 μg/ml), excess magnesium , and calcium withdrawal inhibited the acetylcholine release induced by nicotine or by DMPP.”