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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Abstract Based on preclinical studies suggesting that magnesium (Mg) reduces cocaine selfadministration and potentiates the antinociceptive effects of morphine , we conducted a preliminary randomized clinical trial investigating Mg for the treatment of illicit cocaine and opiate use.”
A Preliminary, Controlled Investigation of Magnesium L-Aspartate Hydrochloride for Illicit Cocaine and Opiate Use in Methadone-Maintained Patients“Conclusions: In the immediate postoperative period, the addition of magnesium or ketamine to morphine for intravenous patient‐controlled analgesia led to a significantly lower consumption of morphine.”
“In experimental studies, administration of magnesium while inducing morphine dependence in rats reduced the dependence intensity.”
“There is evidence that magnesium deficit is involved in addiction to various addictive substances (heroin, morphine , cocaine, nicotine, alcohol, caffeine, and others).”
“Harris et a[. [I21 have demonstrated that prior administration of calcium (as well as magnesium or manganese) to mice prevented the analgesic effect of a single dose of morphine and also that calcium was a more effective antagonist in morphinetolerant mice than in nontolerant animals.”
“Postoperative … in morphine iv equivalents (mean difference -9.24 [95 %CI -13.31, -5.17] mg; ….001) and VAS scores at all-time points of assessment were lower in magnesium group ; this effect peaked at 4 h (mean difference -2.… [95 %CI -3.21,-1.09; p = 0.001].”
“In comparison with placebo, postoperative morphine consumption at 24-h was significantly reduced in the magnesium group , with a mean difference [95% confidence interval (CI)] of -5.6 mg (-7.54 to -3.66, P < 0.001, I = 92%, level of evidence low).”
“The amount of morphine needed in the Mg group was significantly lower than in the C group (5.64 ± 1.69 mg/24 hr versus 8.44 ± 3.98 mg/24 hr; p < 0.001).”
“Cumulative morphine consumption and pain scores were found to be higher in the control group than the magnesium group.”
“The purpose of this study was to establish whether the analgesic effect of morphine improves in patients with cancer when administered in combination with magnesium.”
“A significant decrease in morphine usage by those patients who received magnesium was noted (WMD = -7.40; 95% CI: -9.40 to -5.41, p < 0.00001).”
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