Possible Interaction: Magnesium and Manganese

“We also explore the effect of divalent cations as catalytic cofactors for G2019S LRRK2‐mediated tau phosphorylation and show that manganese does not support kinase activity but inhibits the efficient ability of magnesium to catalyze LRRK2‐mediated phosphorylation of tau.”

“Binding of manganese and magnesium is vital to integrin-mediated cancer cell adhesion and migration.”

“Firstly, there is considerable magnesium present in the bone and this produces a spectral interference with the manganese.”

“ Manganese and magnesium bestowed a weaker association, and copper did not facilitate the protein interactions.”

“In addition, the enzyme activity was stimulated by the divalent cation, manganese , and inhibited by addition of magnesium.”

“Interestingly, when calcium ions were first removed from LFA-1, treatment of lymphocytes with magnesium and manganese ions gave significantly higher levels of conjugation than in the presence of calcium.”

“Analysis of octahedral complexes of magnesium and manganese show that the partial charge of magnesium is higher than that of manganese and the slightly larger size of manganese ion makes its ionic potential smaller.”

“The incorporation of manganese levels in addition to magnesium significantly refined explanatory ability, even though manganese alone was not significantly associated with CWD.”

“A strong interaction (P<0.001) between increasing Mn and adequate Mg on hematology was observed.”

“It has previously been reported that moderately high dietary manganese Mn ) in combination with marginal magnesium (Mg) resulted in ultrastructural damage to heart mitochondria.”

“ Manganese may accumulate and substitute for Mg during the condition of Mg‐deficiency.”

“We also show that the rate of MSP polymerization associated with movement of vesicles in an in vitro motility assay is enhanced by the presence of magnesium and manganese ions and use NMR to show that the primary residues that bind these ions are 24-25 and 83-86.”