Possible Interaction: Magnesium and Magnesium Sulfate

“The umbilical venous ionized magnesium concentration was significantly higher in the magnesium sulfate group (2.32 +/- 0.27 mg/dL vs 1.23 +/- 0.15 mg/dL; P <.001).”

“We concluded that a bolus of 60 mg/kg of MgSO4 leads at least after 90 min to a significant increase in the CSF magnesium concentration.”

“Erythrocyte magnesium (ery-Mg) levels increased significantly after MgSO4 infusion in women with PRP (2.43 +/- 0.13 vs. 2.52 +/- 0.15 mmol l-1, P < 0.05) but not in the controls (2.51 +/- 0.24 vs. 2.57 +/- 0.28 mmol l-1, ns).”

“Preprocedural increase in magnesium (odds ratio 0.68 [0.52–0.85]) and dose of preprocedural magnesium sulfate (odds ratio 0.67 [0.40–0.97]) were associated with reduced CTH risk after adjustment for initial magnesium and other risk factors.”

“For these reasons, the observed serum magnesium increases of 0.07 to 0.11 mEq/L per 1 g of intravenous magnesium sulfate are understandably lower than the increase we expected in our patients (0.15 mEq/L per 1 g of intravenous magnesium sulfate).”

“There was a significant correlation between the full dose of MgSO4 received by the mother and the levels of magnesium in the neonate in the first 24 hours of life (r2 = 0.397; p < 0.001).”

“There was a significant correlation between the full dose of MgSO4 received by the mother and the levels of magnesium in the neonate in the first 24hours of life (r2 0.436; P<.001).”

“Conclusions: Maternal serum concentrations of magnesium are lower in twin pregnancies than in singleton ones following MgSO4 treatment, which might explain the decreased neuroprotective effect of MgSO4 reported in twin pregnancies.”

“Serum magnesium improved with oral magnesium sulfate.”

“Within the range of serum Mg considered, the addition of magnesium sulfate in vitro causes an exponential increase in Mg (2+) and no significant change in serum Ca (2+).”