Possible Interaction: Magnesium and Ibutilide

“In conclusion, the administration of high doses of magnesium probably makes ibutilide a much safer agent, and magnesium increased the conversion efficacy of ibutilide.”

“Background: A previous randomized trial found that adjunctive use of intravenous magnesium (a total of 4 grams) can attenuate the corrected QT interval (QTc) prolongation associated with ibutilide , but its impact on ibutilide efficacy has not been elucidated.”

“Within antiarrhythmic drug treatments, magnesium added onto ibutilide was shown to be more cost effective than ibutilide alone.”

“AbstractBackground: In the Treatment with Ibutilide and Magnesium Evaluation (TIME) study, a retrospective multicentre cohort trial, prophylactic magnesium was found to improve the antiarrhythmic efficacy of ibutilide as demonstrated by an increase in the rate of successful chemical conversion and reduction in the need for direct current cardioversion (DCC).”

“CONCLUSIONS Pre-injection of ma nesium si gnificantly enhances the efficacy of ibu tilide fo r the conversion of TAF but not of AAF.”

“In patients with TAF, pre-injection of magnesium significantly improved the efficacy of ibutilide for conversion (85% with magnesium vs. 59% with placebo, p=0.017).”

“Retrospective cohort evaluations found that intravenous application of magnesium enhances the efficacy of ibutilide for chemical conversion of these arrhythmias.”

“BACKGROUND Intravenous magnesium reduces the QTc interval of patients receiving ibutilide.”

“Background: Intravenous magnesium reduces the QTc interval of patients receiving ibutilide.”

“The efficacy of ibutilide was enhanced by concomitant administration with intravenous magnesium.”