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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Lysine and Urokinase-Type Plasminogen Activator

supplement:

Lysine

drug:

Urokinase-Type Plasminogen Activator

Research Papers that Mention the Interaction

“The inhibitory concentrations 50% of lysine against urokinase or tissue-type plasminogen activator is 2.0 or 4.2 mM, against ε-amino-caproic acid 0.7 or 1.5 mM, against tranexamic acid 0.03 or 0.17 mM, respectively.”
In Vitro Simulation of Thrombolysis Inhibition
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis  •  2008  |  View Paper
“Similarly, Glu-plasminogen activation was augmented by lysine or soluble fibrin.”
Activation of plasminogen by single-chain urokinase or by two-chain urokinase--a demonstration that single-chain urokinase has a low catalytic activity (pro-urokinase).
Blood  •  1987  |  View Paper
“Arginine and lysine esters are competitive inhibitors of the proteolytic activity of plasmin (3) as well as of the activator activity of urokinase , streptokinase, and trypsin (1).”
xi-Aminocaproic acid: an inhibitor of plasminogen activation.
The Journal of biological chemistry  •  1959  |  View Paper