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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Lysine
supplement:
Tryptophan
Research Papers that Mention the Interaction
“A quadratic effect of L* light and marbling in the longissimus dorsi was observed as the dietary SID Trp to Lys ratio increased ( < 0.05).”
The appropriate standardized ileal digestible tryptophan to lysine ratio improves pig performance and regulates hormones and muscular amino acid transporters in late finishing gilts fed low-protein diets.“We hypothesized that excess Lys might improve the conversion of Trp to niacin by causing a buildup of alpha-ketoadipic acid, thereby endproduct inhibiting the main Trp catabolic pathway and resulting in more niacin synthesis from Trp.”
“Generally, Trp addition linearly increased gain and feed intake at a Thr: Lys ratio of 0.60 and 0.65 but not at a Thr:Lys ratio of 0.55.”
“At similar concentration (0.04 mM) to L-tryptophan, lysine , methionine and alanine in the presence of Na + also stimulated L-tryptophan uptake.”
“The present results suggest that methionine was the first-limiting and that lysine was probably the second-limiting amino acid for the corn and soybean meal diet in weaned calves less than 11 wk of age, although tryptophan may be either co-limiting with lysine or third-limiting.”
“The oxidation of lysine was also reduced by increasing tryptophan levels to 2 g/kg; as tryptophan level was increased to 3 g/kg there was no statistically significant reduction of lysine oxidation.”
“4) The intracellular concentration of lysine and of tryptophan, [Lys]c and [Trp]c, are unaffected by … and lysine, respectively, although the transmural fluxes, from the mucosal side to the serosal side, Jms, of lysine , Jms-Lys, and of tryptophan, Jms-Trp, are inhibited by tryptophan and lysine, respectively.”
“1 mM lysine inhibited the uptake of 1 mM alanine, leucine, methionine, phenylalanine, threonine and histidine but not 1 mM valine, isoleucine, tryptophan and proline by epithelial cells isolated from rat intestine.”
“ Lysine inhibited the transport of tryptophan when a part of the intestinal capacity for transport of neutral amino acids was occupied by methionine; 6.”
“ Tryptophan was a potent competitive inhibitor of the transport of lysine ; 5.”
“Furthermore, the substitution of tryptophan with lysine in the H‐CDR3 increased charge heterogeneity of the product.”
Modeling the impact of amino acid substitution in a monoclonal antibody on cation exchange chromatography
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