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“The exposure of these fibrils to trypsin generates a cleavage at the C-terminal of lysine 6 and creates the 7–99 truncated form of β2-m (ΔN6β2-m) that is a ubiquitous constituent of the natural β2-m fibrils.”
Journal of Biological Chemistry • 2008 | View Paper
“Additionally, the presence of Arg and Lys renders the peptides susceptible to degradation by proteases, such as trypsin , limiting their therapeutic use.”
“ Lysine in CPTI-II binds deeper in the specificity pocket of bovine trypsin than lysine in other known lysine-bovine-trypsin complexes, and anionic salmon trypsin lacks some of the secondary binding interactions found in the complexes formed between squash inhibitors and bovine trypsin.”
“ Trypsin , Phospholipase-D and Neuraminidase at different concentrations inhibited significantly (P less than 0.001) lysine accumulation in rat intestinal cells, whereas Chymotrypsin did not show any significant effect.”
European journal of biochemistry • 1976 | View Paper
“With the L-lysine methyl esters the catalytic rate constant for hydrolysis (kcat) was found to be significantly lower for alpha-trypsin than for beta-trypsin, whereas with N2-benzoyl-L-arginine ethyl ester there was no significant difference for the two enzymes.”
European journal of biochemistry • 1976 | View Paper
“The electrophoretically pure preparation which inhibits trypsin in a specific manner is a relatively small peptide containing 5 Asp, 4 Thr, 1 Ser, 11 Glu, 6 Pro, 6 Gly, 5 Ala, 2 Val, 10 (Cys)1/2, 3 Ile, 2 Phe, 7 Lys , 3 Arg and 1 Try.”