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“We show that SFN treatment causes a concentration-dependent reduction in PcG protein (Bmi-1, Ezh2) expression in SCC-13 skin cancer cells and also reduces trimethylation of lysine 27 of histone H3.”
“ SFN is found to bind covalently and specifically with the free NH(2) group of N-terminal aspartic acid and the ε-amino group of lysine at positions 16 and 28.”