Possible Interaction: Lysine and Serine

“Methylation of lysine 9 interferes with phosphorylation of serine 10 , but is also influenced by pre-existing modifications in the amino terminus of H3.”

“Specifically, lysine 370/372/373 and 381/382/386 mutations decreased p53 stability, and lysine 305 mutation reduced p53 phosphorylation level at serine 15 , while lysine 120 and 164 mutations decreased p53 acetylation level at lysine 382.”

“Plasma concentrations of Lys linearly increased ( < 0.001), but Leu, Ser , Val, and Tyr ( ≤ 0.02) were linearly reduced by Lys supplementation, likely reflecting increased uptake for protein deposition.”

“Substitution of lysine (or arginine) with serine rendered the matrices insensitive to the action of plasmin.”

“Experiments were done on three groups of rats given diets containing 10% gluten, 10% gluten+0.5% L-lysine or 10% gluten+….2% L-threonine and 0.2% L-methionine for 10 d. The urinary excretion of urea, and the liver concentrations of serine and … of dietary L-lysine, ….”

“Extractions of Asp, Glu, Ser , Asn, Gly, Gln, Tau, His, Cit, Thr, Pro, Tyr, Val, cystine, Ile, Leu, Trp, Orn, and Lys also were correlated with arteriovenous differences of Met.”

“… Ser‐10 lowers the rate … chemical acetylation of Lys‐9 , Lys‐14, and Lys‐18 by methyl acetyl phosphate in that order consistent with a higher pKa of these Lys … induced by phosphorylation; basicities increase up to 3 pKa units as a function of distance from Ser‐10 phosphate.”

“A Ser-X-X-Lys sequence motif is seen in all these proteins, and crystal structures demonstrate that the side-chain functions of the serine and lysine are in contact with one another.”

“When the arginines are replaced with lysines , the stabilizing effect of serine phosphorylation is reduced (δδGP = ‐0.5 kcal mol−1 dimer−1).”