Possible Interaction: Lysine and Proline

“Inhibition of the posttranslational hydroxylation of lysine and proline resulted in comigration of human and mouse alpha 1 and alpha 2 chains, suggesting that increased posttranslational modification caused the altered electrophoretic migration in the human-mouse hybrid molecules.”

“Notably, we found that a proline or glycine residue in front of the substrate lysine has a strong adverse effect on the substrate reactivity as compared to a preceding leucine, serine, alanine or arginine residue.”

“Glycine, lysine , arginine, valine, isoleucine, and tryptophan in the second position are (with N-terminal serine) strongly inhibitory, and proline completely blocks modification.”

“1 mM lysine inhibited the uptake of 1 mM alanine, leucine, methionine, phenylalanine, threonine and histidine but not 1 mM valine, isoleucine, tryptophan and proline by epithelial cells isolated from rat intestine.”

“The free amino acid composition, serine, lysine , histidine, and arginine levels were significantly lower in the PRO than in the control group.”

“In the developing endosperm, the saccharopine pathway is induced by exogenous lysine and repressed by salt stress, whereas proline and pipecolic acid synthesis are significantly repressed by lysine.”

“We found that acetylation of lysine 14 in the histone H3 N-terminal tail (H3K14ac), an intrinsically disordered domain, increased the proportion of neighbouring proline 16 (H3P16) in the trans conformation.”

“Abstract Growth ofSaccharomyces cerevisiaeon poor nitrogen sources such as allantoin or proline is totally inhibited by addition of lysine to the medium.”