Possible Interaction: Lysine and Phenylalanine

“Since the neutral,l, α-amino acid fluxes are insensitive to MeAIB, we conclude that they are not mediated by the classicalA system, … of thel-alanine flux is inhibited by phenylalanine, we conclude that it is not mediated by the classicalASC system.l-alanine and phenylalanine completely … of lysine.”

“We demonstrate that, like alanine, glycine and leucine, phenylalanine shares sodium‐dependent as well as sodium‐independent transport with lysine.”

“A 20-fold excess of unlabeled leucine, isoleucine, methionine, valine, alanine, lysine , histidine, phenylalanine, and glutamine inhibited uptake of leucine and phenylalanine , and six of these amino acids inhibited uptake of alanine, by more than 50% both in the presence and absence of a potassium ion gradient.”

“Reduction of … levels of lysine , threonine and methionine from the generous levels characteristic of a diet containing 240 g protein from skim milk/kg, to the requirement … determined separately in the presence of the generous levels of all the other amino acids, resulted in a twofold increase in phenylalanine ….”

“However, the rates of absorption of methionine, arginine, leucine and phenylalanine were higher than those of lysine , threonine and histidine irrespective of the hydrolysate source.”

“Several hydrophobic ligands in solution enhanced to some extent the enzyme retardation on columns … directly attached to the solid support, while several amino- and guanidino-alkylcarboxylic acids lysine and arginine analogs) greatly … enzyme retardation on the phenylalanine column and somewhat enhanced it on … other columns having hydrophobic spacer arms.”

“In contrast, the plasma levels of phenylalanine , tyrosine, tryptophan and methionine elevated by the excessive feeding of corresponding amino acid were decreased fairly by the supplement of lysine.”

“1 mM lysine inhibited the uptake of 1 mM alanine, leucine, methionine, phenylalanine , threonine and histidine but not 1 mM valine, isoleucine, tryptophan and proline by epithelial cells isolated from rat intestine.”

“ Lys and His supplementations increased the consumption of Glu and Phe , and decreased the consumption of Ser, Trp and Arg.”

“With dGTP, the contribution of Arg remains the same, but the additional interactions are provided by both Lys and Phe , suggesting that the binding of the incoming dNTP is not identical under all circumstances.”