Possible Interaction: Lysine and Penicillins

“The amount of penicillin produced increased as the level of lysine in the media was increased.”

“The addition of 0.1 M L-lysine to the fermentation medium reduced the production of penicillin by about 50% in Aspergillus nidulans.”

“This can be correlated with the disruption of the predicted electrostatic binding between the C3 carboxylic group of penicillins and the amine function of the lysine.”

“ Lysine decreases the biosynthesis of penicillin (determined by the incorporation of [14C]valine into penicillin) by inhibiting and repressing homocitrate synthase, thereby depriving the cell of alpha-aminoadipic acid, a precursor of penicillin.”

“ Lysine inhibited total penicillin synthesis to a similar extent in both strains.”

“The inhibitory effect of L-lysine on penicillin biosynthesis by Penicillium chrysogenum has been compared in a low-producing strain (Wis. 54-1255) and a high-producing strain (ASP-78).”

“We show that these cells incorporate radioactive L-lysine into their cell wall peptidoglycan and that the incorporation is inhibited by penicillin G. Approximately 40% of the radioactive lysine incorporated into the cell wall in the absence of penicillin, participates in the formation of peptide cross-links via”

“When the mutant strain … similar conditions, penicillin production … as lysine feed concentrations increased until at 180% excess over that required for growth, a q pen of 2·64 u/mg …/h was reached, after which the q pen fell at a rate similar to that of the parent strain.”

“Antibiotics that inhibit the biosynthesis of the cell wall, such as vancomycin, penicillin , d-cycloserine, and bacitracin, stimulate the incorporation of lysine into lipids that are extractable with n-butanol-6 M pyridinium acetate.”

“Vancomycin and penicillin stimulate the incorporation of lysine into both LPG and the minor lipid fractions, whereas treatment with d-cycloserine results in an increase only in LPG.”

“The known diminution in penicillin formation by added lysine is thought to occur via feedback regulation of the lysine biosynthetic pathway, thus depleting the cells of α-aminoadipic acid, a precur...”