Possible Interaction: Lysine and Nitric Oxide

“Among EleAA, Lys , Trp, His, and Arg (4AA) markedly decreased nitric oxide production and inhibited nuclear factor-κB (NF-κB) activation.”

“ResultsPre- or post-treatment with L-lysine led to significant decreases in the levels of malondialdehyde and nitric oxide , while significant enhancement was observed in the activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and glutathione (p < 0.001).”

“Further, l-Lysine , a competitive inhibitor of l-Arg uptake, repressed nitric oxide production and reduced myotube density and fusion index.”

“ NO concentration in the renal inner medulla, measured with a microdialysis-oxyhemoglobin trapping technique, was significantly decreased by 26-44% … laser Doppler flowmetry, was significantly reduced by 20-24% during the acute renal medullary interstitial infusion of L-ornithine, L-lysine , and L-homoarginine (1 …; n = 6-8/group).”

“Renal medullary infusion … per min) or l-lysine (50 &… NO in the medulla (vehicle, 124±11 nmol/L; l-ornithine, 45±4 nmol/L; l-lysine, 42±6 nmol/L) … mm Hg; l-ornithine, 143±6 mm Hg; l-lysine, 148±3 mm Hg) after 5 days of infusion.”

“Interferon-gamma in combination with tumor necrosis factor-alpha induced nitric oxide production with an enhancement in cationic amino acid transporter-2B mRNA expression, inducible nitric oxide synthase mRNA expression, and L-arginine transport, while extracellular L-lysine competitively inhibited this nitric oxide production.”

“5 In conclusion, L‐lysine , an inhibitor of cellular L‐arginine uptake, reduces NO production and exerts beneficial haemodynamic effects in endotoxaemic rats.”

“Experiments reported here show that L-lysine , a competitive antagonist of L-arginine uptake, suppressed NO production (detected as nitrite accumulation) by interleukin (IL)-1β and interferon (IFN) -pretreated cardiac myocytes by 70%, demonstrating that NO production is dependent on L-arginine uptake.”