Possible Interaction: Lysine and Methionine

“Previous studies have shown that lysine to methionine histone mutations are potent inhibitors of their respective lysine methyltransferases.”

“We conclude that biotinylation of lysines synergizes with sulfoxidation of methionines in heat shock proteins such as HSP60 in the defense against reactive oxygen species.”

“In solutions containing sodium the entry of lysine through the high‐affinity system (y+L) is inhibited by the neutral amino acids L‐leucine, L‐methionine and L‐glutamine with comparable high affinity.”

“Leucine and methionine , but apparently not glutamine, inhibit lysine entry through system y+ with a much lower affinity.”

“Overall, balancing for Lys and Met at a 3:1 ratio increased intracellular concentrations of Lys and Met by 54 and 71%, respectively.”

“Supplementation of Met or Lys significantly increased Met or Lys concentration in arterial plasma.”

“Results also show that negative effects on performance of lactating dairy cows can occur if methionine is supplied at levels substantially in excess of calculated intestinally absorbable requirements, either alone or together with lysine.”

“Administration of methionine plus lysine resulted in a remarkable increase in plasma methionine (Trials 1 and 2), especially at the lower intake level (Trial 1), and a decrease in plasma branched-chain amino acids at either intake level.”

“At Stage 2, administration of the same levels of methionine and lysine resulted in reduced feed intake, depressed nitrogen retention, and BW loss.”

“The addition of 5.75 or 8.5% FM or 5.75% FM plus Met and Lys generally increased (P < 0.05) early egg production and postmolt body weight gain compared to the corn basal diet in Experiment 3.”

“Supplementation of Met and Lys increased the milk yield of cows previously fed the low RUP diet, but milk yields before and after amino acid (AA) supplementation were similar for cows previously fed the high RUP diet.”