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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Lysine
drug:
Hypochlorite
Research Papers that Mention the Interaction
“The reaction of protein with HOCl resulted in changes in protein conformation as assessed by the UV fluorescence and oxidation of the unique methionine and tyrosine, chlorination of several lysines with formation of chloramines.”
Oxidation of Cu,Zn-superoxide Dismutase by the Myeloperoxidase/Hydrogen Peroxide/Chloride System: Functional and Structural Effects“Flecks et al. suggested that a concerted interaction of hypochlorous acid with the lysine and the glutamate residue should increase the electrophilicity of the chlorine species and in addition ensure the correct positioning of the chlorine species for the regioselective incorporation of chlorine into the indole ring of tryptophan.”
Changing the regioselectivity of the tryptophan 7-halogenase PrnA by site-directed mutagenesis.
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