Possible Interaction: Lysine and Glutamic Acid

“Substitution of malonylated lysine residue 184 in glyceraldehyde 3-phosphate dehydrogenase with glutamic acid , a malonyllysine mimic, suppressed its enzymatic activity.”

“Substitutions of lysine for glutamic acid in positions beta 66 and beta 95 perturb the formation of the cytochrome b5--hemoglobin complex and result in a dramatic impairment of the cytochrome b5-mediated reduction, whereas the same mutation in position alpha 16 has no effect.”

“In Api g 1.01, substitution of lysine against glutamic acid at amino acid position 44, a key residue of the Bet v 1 "P-loop", increased the IgE-binding properties.”

“The G1123A mutation, resulting in the substitution of Glu 375 > Lys, breaks down the possible interaction of glutamic acid with neighboring lysine and causes electrostatic and steric repulsion, which is likely to destabilize structure in this part of the protein.”

“Replacement of the Lys or the Ile residues with Glu abolished the binding activity.”

“Activity decreased more than 90 percent on substitution of glutamic acid 245 with lysine.”

“Kinetic constants were significantly less perturbed when Glu was 2 or more residues distant from Lys.”

“Extractions of Asp, Glu , Ser, Asn, Gly, Gln, Tau, His, Cit, Thr, Pro, Tyr, Val, cystine, Ile, Leu, Trp, Orn, and Lys also were correlated with arteriovenous differences of Met.”

“Stimulation had no significant effect on uptake of lysine , phenylalanine, or GABA but was found to potentiate uptake of glutamic acid by 12%.”

“The genetic factors involved in … response to the copolymer of l-glutamic acid … l-lysine (GL), responsiveness which is linked to the I-region of the strain 2 major histocompatibility complex, have … analyzed by in vitro priming of nonimmune T lymphocytes with GL-pulsed syngeneic or semi-syngeneic macrophages.”