Possible Interaction: Lysine and Aspartate

“Conversely, the exchange of aspartate 100 by lysine in the mV(2)R increased the cell surface expression and resulted in predominant plasma membrane localization.”

“The exchange of lysine 100 by aspartate in the first extracellular loop of hV(2)R was sufficient to reduce cell surface expression, which was accompanied by intracellular retention as observed in laser scanning microscopy analysis.”

“A total of 28 … of them including lysine , linoleic acid, 3-hydroxybutyric acid, prostaglandin F2a, taurocholic acid, LysoPC(15:0), l-carnitine, glucose, arginine, citric acid, corticosterone, ornithine, …, which mainly related with 13 metabolic pathways, such as linoleic acid metabolism, starch, and sucrose metabolism, arachidonic acid metabolism, alanine, aspartate ….”

“These are mainly stabilized compared to the homodimers by re-establishment of the wild-type hydrophobic interaction at the not mutated residues while an interaction of aspartate and lysine seems energetically unfavorable in this structural context.”

“An … lysine of the NKXD … and an aspartate in the inserted helical domain of alpha subunits of heterotrimeric G proteins, Lys-278 and Asp-158, respectively, of Gs alpha … essential for activation by AlF4- and partially so for interaction with beta gamma dimers and activation by GTP and receptor.”

“AMP, ADF, inorganic pyrophosphate, CTP, GTP, UTP, dATP, dCTP, dGTP, dTTP, and lysine inhibited the activity, while aspartate stimulated it.”

“In this concentration range heroin increases the rate of accumulation in the free amino acid "pool" of aspartate , glutamate, and alanine, inhibits the accumulation of lysine and proline, and has no effect on the accumulation of five other amino acids tested.”