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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Lysine
supplement:
Alpha-Ketoglutarate
Research Papers that Mention the Interaction
“In the direction of reductive condensation of lysine and alpha-ketoglutarate (reverse reaction), the V/K profile for lysine shows a group with a pK of 6.3 must be unprotonated and a group with a pK of 8.0 must be protonated for activity.”
Chemical mechanism of saccharopine dehydrogenase (NAD+, L-lysine-forming) as deduced from initial rate pH studies.“The activity is completely inhibited in vitro by lysine and by some lysine analogs, which all show cooperative binding and have an heterotropic effect on 2-ketoglutaric binding sites.”
“In the direction of reductive condensation of alpha-ketoglutarate and lysine , saccharopine dehydrogenase (N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (lysine-forming) is inhibited by high concentrations of alpha-ketoglutarate and lysine, but not by NADH.”
“The enzymatic formation of HC from alpha-ketoglutarate plus acetyl-coenzyme A in cell-free extracts of the same organism was also inhibited by lysine.”
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