Possible Interaction: Lycopene and Simvastatin

“After adjustment for lipids, the levels of lutein, lycopene , α-carotene and β-carotene were significantly increased by simvastatin suggesting an increased ratio of carotenoids per particle.”

“The results showed that lycopene and simvastatin applied together reduced TNFα and IFNγ secretion, and abolished the increased production of the proinflammatory cytokine IL-1γ caused by incubation with simvastatin only, an observation suggesting that simultaneous administration of both substances may reduce inflammatory responses.”