Possible Interaction: Lutein and Zeaxanthin

“Significant correlations were found between retinal lutein and zeaxanthin (macular pigment) and CFF thresholds (p<0.01) and visual motor performance (overall p<0.01).”

“Epidemiologic research shows an inverse association between levels of lutein and zeaxanthin in eye tissues and age related degenerative diseases such as macular degeneration (AMD) and cataracts.”

“Increased macular carotenoid levels result from supplementation of humans with lutein and zeaxanthin.”

“The combined concentration of lutein plus zeaxanthin was 70% higher in human ROS than in residual membranes.”

“ Zeaxanthin concentrations are 2.5-fold higher than lutein in the cone-dense central fovea.”

“Recently a randomised controlled trial of people with AMD showed that among people who have a low intake of lutein from diet, people who consumed a supplement of 10 mg of lutein and 2 mg of zeaxanthin had a slower progression of AMD.”

“Aims To investigate functional and macular pigment (MP) changes in patients with early age-related macular degeneration (AMD) after multiple supplementation with lutein and zeaxanthin.”

“Dietary intake of these carotenoids was significantly related with a reduction in risk of late AMD (RR …·74; 95 % CI 0·57, 0·97); and a statistically significant inverse association was observed between lutein … zeaxanthin intake and neovascular AMD risk (RR 0·68; 95 % CI 0·51, 0·92).”

“Purpose Epidemiological studies suggest that dietary intake of lutein and zeaxanthin is inversely related to the risk for senile cataract.”

“We have previously reported that consumption of lutein and zeaxanthin as 2 and 4 egg yolks per day for 5 weeks significantly increased serum lutein and zeaxanthin concentrations in older adults taking cholesterol-lowering statins.”