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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Lutein
supplement:
Beta Carotene
Research Papers that Mention the Interaction
“The relative bioavailability of lutein from vegetables is higher than that of beta-carotene.”
“When combined in the same dose, beta-carotene significantly reduced the serum AUC values for lutein to 54-61% of control values (P < 0.025), whereas lutein reduced the AUC value for beta-carotene in five subjects but enhanced it in three subjects.”
“Much of the evidence suggests an interaction between beta-carotene and oxycarotenoids such as canthaxanthin and lutein , and between the hydrocarbon carotenoids beta-carotene and lycopene.”
“Results indicate an inhibitory effect of lutein on beta-carotene absorption , but apparently not on beta-carotene cleavage.”
“At equimolar concentrations, lutein had a negative impact on beta-carotene transport and vice versa.”
“In conclusion, this study confirmed that beta-carotene and lutein interact during their absorption, depending on the concentration/ratios used, and that carotenoid absorption is partially affected by ezetimibe.”
“ BC incorporation into bile salt mixed micelles during chemical preparation and during simulated small intestinal digestion of carotenoid-enriched oil was slightly increased when the concentration of LUT was sixfold or more greater than BC.”
“In conclusion, this study showed that lutein , but not lycopene, negatively affected beta-carotene absorption when given simultaneously with beta-carotene but apparently had no effect on beta-carotene cleavage.”
“These analyses suggest that consumption of carotenoids such as lutein in addition to beta-carotene may be associated with a lower risk of cancers.”
“ Lower lutein concentrations in recipients of beta-carotene capsules suggested an interaction between these two carotenoids.”
Plasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men.“More importantly, beta-carotene decreased the concentrations of both lutein and zeaxanthin in the plasma and most tissues, including the retina.”
“The retina appears to have the capacity to preserve accumulation of lutein and zeaxanthin, but this capacity is diminished when intake of beta-carotene is high.”
Competitive inhibition of carotenoid transport and tissue concentrations by high dose supplements of lutein, zeaxanthin and beta-carotene
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