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Last Updated: 2 years ago

Possible Interaction: Lovastatin and Ubiquinone

supplement:

Ubiquinone

Research Papers that Mention the Interaction

Lovastatin treatment resulted in a decrease in ubiquinone (97.9 ± 14.9; control: 202.9 ± 18.4 pmol/mg; p < 0.05), and complex IV activity (0.008 ± 0.001; control: 0.011 ± 0.001; p < 0.05) relative to control.
Toxicology mechanisms and methods  •  2009  |  View Paper
Mevinolin pretreatment decreased the incorporation rate of [3H]-mevalonate into cholesterol but increased the labeling of ubiquinone and dolichol both in diseased and control cells.
Pediatric Research  •  1999  |  View Paper
Mitochondrial ubiquinone is decreased in cell cultures exposed to lovastatin , but serum concentrations of ubiquinone have been noted to be unchanged in patients taking hydroxymethylglutaryl coenzyme A reductase inhibitors.'
The Medical journal of Australia  •  1990  |  View Paper
Mitochondrial ubiquinone is decreased in cell cultures exposed to lovastatin , but serum concentrations of ubiquinone have been noted to be unchanged in patients taking hydroxymethylglutaryl coenzyme A reductase inhibitors.'
The Medical journal of Australia  •  1990  |  View Paper
It is concluded that lovastatin does indeed lower tissue concentrations of CoQ and that a return to normal can be achieved by supplementation with CoQ.
Proceedings of the National Academy of Sciences of the United States of America  •  1990  |  View Paper
Supplementation with CoQ10 did not modulate the effect of ethanol on retinal palmitate, but it did reverse the effect of lovastatin on CoQ9.
Molecular aspects of medicine  •  1994  |  View Paper
Lovastatin , a cholesterol-lowering drug, decreased plasma cholesterol and cardiac tissue coenzyme Q10 levels in guinea pigs given 20 mg per kg body weight twice a day.
Biochimica et biophysica acta  •  1994  |  View Paper
Our results indicate that lovastatin significantly decreased ubiquinone concentrations in the heart (-33%, P < 0.01) but not in the liver (-23%, NS) when compared to controls, whereas fenofibrate did not alter these parameters.
Biochimica et biophysica acta  •  1993  |  View Paper
It is concluded that lovastatin does indeed lower tissue concentrations of CoQ and that a return to normal can be achieved by supplementation with CoQ.
Proceedings of the National Academy of Sciences of the United States of America  •  1990  |  View Paper
At a concentration of 25 microM, mevinolin completely inhibited the incorporation of [3H]acetate into ubiquinone , isolated from cell extracts by two-dimensional thin-layer chromatography.
The Journal of biological chemistry  •  1985  |  View Paper