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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Lovastatin
supplement:
Ubiquinone
Research Papers that Mention the Interaction
“ Lovastatin treatment resulted in a decrease in ubiquinone (97.9 ± 14.9; control: 202.9 ± 18.4 pmol/mg; p < 0.05), and complex IV activity (0.008 ± 0.001; control: 0.011 ± 0.001; p < 0.05) relative to control.”
Decreased Ubiquinone Availability and Impaired Mitochondrial Cytochrome Oxidase Activity Associated With Statin Treatment“ Mevinolin pretreatment decreased the incorporation rate of [3H]-mevalonate into cholesterol but increased the labeling of ubiquinone and dolichol both in diseased and control cells.”
“ Mitochondrial ubiquinone is decreased in cell cultures exposed to lovastatin , but serum concentrations of ubiquinone have been noted to be unchanged in patients taking hydroxymethylglutaryl coenzyme A reductase inhibitors.'”
“ Mitochondrial ubiquinone is decreased in cell cultures exposed to lovastatin , but serum concentrations of ubiquinone have been noted to be unchanged in patients taking hydroxymethylglutaryl coenzyme A reductase inhibitors.'”
“It is concluded that lovastatin does indeed lower tissue concentrations of CoQ and that a return to normal can be achieved by supplementation with CoQ.”
“Supplementation with CoQ10 did not modulate the effect of ethanol on retinal palmitate, but it did reverse the effect of lovastatin on CoQ9.”
Effects of ethanol, lovastatin and coenzyme Q10 treatment on antioxidants and TBA reactive material in liver of rats.“ Lovastatin , a cholesterol-lowering drug, decreased plasma cholesterol and cardiac tissue coenzyme Q10 levels in guinea pigs given 20 mg per kg body weight twice a day.”
“Our results indicate that lovastatin significantly decreased ubiquinone concentrations in the heart (-33%, P < 0.01) but not in the liver (-23%, NS) when compared to controls, whereas fenofibrate did not alter these parameters.”
“It is concluded that lovastatin does indeed lower tissue concentrations of CoQ and that a return to normal can be achieved by supplementation with CoQ.”
“At a concentration of 25 microM, mevinolin completely inhibited the incorporation of [3H]acetate into ubiquinone , isolated from cell extracts by two-dimensional thin-layer chromatography.”
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