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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Lovastatin
supplement:
Tocotrienols
Research Papers that Mention the Interaction
“ γ-Tocotrienol enhanced the apoptotic effect of lovastatin through the down-regulation of GLO1 and HMGCR resulting in an increase of methylglyoxal and a decrease of cholesterol and led to the apoptosis of HL-60 cells.”
Differentiation and apoptosis induction by lovastatin and γ-tocotrienol in HL-60 cells via Ras/ERK/NF-κB and Ras/Akt/NF-κB signaling dependent down-regulation of glyoxalase 1 and HMG-CoA reductase.“The impact of d-δ-tocotrienol on A2058 cell proliferation was potentiated by lovastatin (IC(50)=3.1 ± 0.5 μmol/l), a competitive inhibitor of HMG CoA reductase.”
“A physiologically attainable blend of d-&dgr;-tocotrienol and lovastatin synergistically suppressed the proliferation of MIA PaCa-2 cells.”
“Rats supplemented with annatto tocotrienol and lovastatin concurrently demonstrated significantly lower single-labeled surface, but increased double-labeled surface, mineralizing surface, mineral apposition rate and bone formation rate compared to individual treatments (p < 0.05).”
“The combination of annatto tocotrienol and lovastatin exerted either additively or synergistically on selected bone parameters.”
The Effects of Tocotrienol and Lovastatin Co-Supplementation on Bone Dynamic Histomorphometry and Bone Morphogenetic Protein-2 Expression in Rats with Estrogen Deficiency“In conclusion, combined treatment of lovastatin and tocotrienol upregulated the expression of genes related to fracture healing.”
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