Possible Interaction: Lovastatin and Niacin

“To determine if low‐dose lovastatin in combination with niacin causes a greater percentage reduction in low‐density lipoprotein (LDL) cholesterol than lovastatin alone, and to determine if the combination increases the risk of serious adverse effects.”

“Myotoxicity has been observed when lovastatin is coadministered with niacin , and so the combination of niacin with fluvastatin has also been studied to examine the possibility of this effect occurring.”

“Our study indicates that the combination of nicotinic acid (1.2 g/day) and lovastatin (20 mg/day) is more effective than either drug alone in reducing total and LDL cholesterol.”

“Myotoxicity has been observed when lovastatin is coadministered with niacin , and so the combination of niacin with fluvastatin has also been studied to examine the possibility of this effect occurring.”

“All the demonstrated effects of monacolin K were counteracted by nicotinamide or compound C, the inhibitors of SIRT1 or AMPK.”

“The addition of lovastatin to niacin promoted a lowering in LDL apoB-100 attributable to increased LDL apoB-100 FCR.”

“A 54 year old man developed rhabdomyolysis one year after beginning treatment with a combination of lovastatin (an HMGCoA reductase inhibitor) and niacin.”

“The hypocholesterolaemic effects of lovastatin can be potentiated by combination therapy with other currently approved lipid lowering medications including bile acid sequestrants and nicotinic acid.”