“Attempts were made to correct the Mn-… defect by (1) co-administration of mevinolin … Mn for 30 days; (2) administration of mevinolin for 15 days after 15 days of dosing with Mn, … (3) by withdrawal of Mn treatment (15 days dosing with Mn followed by 15 days without Mn).”
“This delay was completely corrected (to 30.7 +/- 6.0 sec) in rats co-administered mevinolin (an inhibitor of cholesterol biosynthesis) with Mn.”