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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Lovastatin
supplement:
Kaempferol
Research Papers that Mention the Interaction
“In Caco-2 cells, demonstrated to contain minimal CYP3A activity, the permeability coefficient of the prodrugs lovastatin and enalapril was increased in the presence of the active flavonoids kaempferol and naringenin, consistent with inhibition of esterase activity.”
“In addition, in portal vein-cannulated rats, coadministration of lovastatin with kaempferol (10 mg/kg) led to a 154% and a 113% increase in the portal plasma exposure to the prodrug and active acid, respectively, compared with coadministration with water.”
Esterase Inhibition by Grapefruit Juice Flavonoids Leading to a New Drug Interaction“As a result, co-administration of lovastatin solid dispersion with kaempferol could be a promising delivery system to improve the oral bioavailability of lovastatin.”
“The oral bioavailability of lovastatin and lovastatin acid after oral administration of lovastatin solid dispersion with 10 mg/kg kaempferol (CYP3A4 inhibitor) were increased about 3.79-fold and 2.51-fold than that of lovastatin suspension, and the absolute bioavailability of lovastatin was up to 33.0%.”
The characteristics and mechanism of co-administration of lovastatin solid dispersion with kaempferol to increase oral bioavailability
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