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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Losartan
supplement:
Paricalcitol
Research Papers that Mention the Interaction
“ Paricalcitol in combination with lozartan has more pronounced nephroprotective effect.”
[The role of D2 vitamin metabolite paricalcitol in nephroprotective strategy in chronic disease of the kidneys].“The histopathological effects related to losartan treatment were found to be reversed when paricalcitol treatment was combined.”
Paricalcitol counteracts the increased contrast induced nephropathy caused by renin-angiotensin-aldosterone system blockade therapy in a rat model.“We recently showed that losartan and paricalcitol are synergistic in the treatment of diabetic nephropathy in a model of type 1 diabetes.”
“Treatment of the diabetic mice with losartan or paricalcitol (19-nor-1,25-dihydroxyvitamin D2, an activated vitamin D analog) alone moderately ameliorated kidney injury; however, combined treatment with losartan and paricalcitol completely prevented albuminuria, restored glomerular filtration barrier structure, and markedly reduced glomerulosclerosis.”
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