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Last Updated: 2 years ago

Possible Interaction: Losartan and Calcium Supplement

Research Papers that Mention the Interaction

Losartan (1 μM) significantly blocked the AII induced BK channel activation (p=0.0131), the Ca2+I response (p<10−4), and the AII induced volume effect (p=0.0046).
The British journal of ophthalmology  •  2002  |  View Paper
Results: This study showed a greater calcium marking in normotensive animals treated with losartan in relation to the other groups.
Journal of applied oral science : revista FOB  •  2019  |  View Paper
The nonpeptide AT1 receptor blocker losartan antagonizes Ang II-induced [Ca2+]i increases in both cell groups, supporting mediation by native AT1B receptors and effective coupling of this subtype to second messenger systems leading to calcium entry and mobilization.
Hypertension  •  1998  |  View Paper
Collectively, these experimental results suggest that losartan at low concentrations inhibits the CA secretion evoked by cholinergic stimulation (both nicotininc and muscarinic receptors) as well as by membrane depolarization from the rat adrenal medulla, but at high concentration it rather inhibits ACh-evoked CA secretion.
Furthermore, in … with losartan (15 microM) …, the CA secretory responses evoked by Bay-K-8644 (10 microM, an activator of L-type Ca(2+) channels), cyclopiazonic acid (10 microM, … cytoplasmic Ca(2+)-ATPase), veratridine (100 microM, an activator of Na(+) channels), and Ang II (100 nM) were markedly inhibited.
However, at high concentrations (150~300 microM), losartan rather enhanced the CA secretion evoked by ACh.
Losartan (5~50 microM) perfused into an adrenal vein for 90 min produced dose- and time-dependent inhibition of the CA secretory responses evoked by ACh (5.32 mM), high K(+) (56 mM, a direct membrane depolarizer), DMPP (100 microM) and McN-A-343 (100 microM).
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology  •  2009  |  View Paper