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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Loperamide
supplement:
Quinidine
Research Papers that Mention the Interaction
“The ABCB1 TT3435 genotype was associated with the most pronounced increase of the miotic effects of loperamide when quinidine was co-administered.”
“When quinidine was co-administered with loperamide , pupil size decreased.”
Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers.“On the basis of in vitro studies demonstrating that loperamide is a substrate for the adenosine triphosphate–dependent efflux membrane transporter P‐glycoprotein, we postulated that inhibition of P‐glycoprotein with quinidine would increase entry of loperamide into the central nervous system with resultant respiratory depression.”
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