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Discover Supplement-Drug Interactions

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Last Updated: a month ago

Possible Interaction: Loperamide and Quinidine



Research Papers that Mention the Interaction

The ABCB1 TT3435 genotype was associated with the most pronounced increase of the miotic effects of loperamide when quinidine was co-administered.
When quinidine was co-administered with loperamide , pupil size decreased.
Pharmacogenetics  •  2003  |  View Paper
On the basis of in vitro studies demonstrating that loperamide is a substrate for the adenosine triphosphate–dependent efflux membrane transporter P‐glycoprotein, we postulated that inhibition of P‐glycoprotein with quinidine would increase entry of loperamide into the central nervous system with resultant respiratory depression.
Clinical pharmacology and therapeutics  •  2000  |  View Paper