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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Loperamide
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“Although these findings might be explained by the involvement of different intracellular ACTH-secreting mechanisms, an influence of loperamide on some suprapituitary factors modulating the ACTH response is suggested.”
“ Loperamide is a peripheral opiate agonist able to inhibit ACTH secretion.”
Loperamide, an opiate analog, differently modifies the adrenocorticotropin responses to corticotropin-releasing hormone and lysine vasopressin in patients with Addison's disease.“While in controls … DXM and LOP strongly suppressed plasma cortisol and ACTH , in Cushing’s disease and in incidentalomas no patient showed a decrease in cortisol levels below 50 ng/ml or a reduction in plasma cortisol greater than 50% of basal values in response to LOP and DXM.”
“ Loperamide is a drug that acts as an opiate agonist and is able to inhibit corticotropin levels in normal subjects and in patients with Addison's disease, but not in patients with Cushing's syndrome.”
“In summary, loperamide is able to reduce basal and CRH-induced ACTH and cortisol levels in normal subjects, but not in patients with Cushing's disease or secondary adrenal failure of hypothalamic origin.”
“ Loperamide , an opiate agonist of high specificity for mu-receptors, was recently reported to suppress ACTH and cortisol levels in normal subjects, but not in patients with proven ACTH-dependent Cushing's disease.”
“In 3 patients treated with antiepileptic drugs ACTH and Cortisol levels were inhibited by loperamide , but not by dexamethasone.”
“In normal subjects plasma ACTH and Cortisol levels were significantly (p < 0.005) suppressed by both loperamide (16 mg po) and dexamethasone (1 mg po).”
“These data suggest that the inhibitory role of loperamide on ACTH secretion is exerted at supra-pituitary level, although a pituitary site of action can not be excluded.”
“After 3.5 h, loperamide (10 microM) had no effect on basal ACTH levels but significantly suppressed CRH-induced ACTH release, in a dose-dependent manner, to 60 +/- 4% of control (100%) (p < 0.0001).”
“ Loperamide did not influence basal and CRH-induced adenylate cyclase activity in anterior pituitary cell membrane preparations, but it significantly blunted Bu(2)cAMP-induced ACTH secretion in cell culture from 100 +/- 4 to 77 +/- 4% (p < 0.05).”
Loperamide inhibits corticotrophic cell function by a naloxone-insensitive mechanism in the rat in vitro.
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