“In conclusion, data from this study suggest that SUN inhibits AMPK downstream signaling with the consequent inhibition of mitochondrial transport of LCFA and energy production in cardiac tissues.”
“This study has … investigate whether sunitinib (SUN) alters the expression of key … mitochondrial transport and oxidation of long chain fatty acids (LCFA), and if so, whether these alterations should be viewed as a mechanism of …, and to explore the molecular mechanisms whereby carnitine supplementation could attenuate SUN-induced cardiotoxicity.”