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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Long Chain Fatty Acid and Doxorubicin Hydrochloride

Research Papers that Mention the Interaction

Adriamycin (ADR) inhibits the carnitine palmitoyl transferase (CPT) system and consequently the transport of long-chain fatty acids across mitochondrial membranes.
Pediatric Research  •  2003  |  View Paper
Recently, it has been suggested that ADR inhibits the carnitine palmitoyltransferase system (CPT I) and consequently the transport of long-chain fatty acids across mitochondrial membranes.
Pediatric Research  •  2002  |  View Paper
Results of this study revealed that ADR induced its cardiotoxicity by inhibition of CPT I and beta-oxidation of long-chain fatty acids with the consequent depletion of ATP in cardiac tissues, and that PLC can be used as a protective agent against ADR-induced cardiotoxicity.
Pharmacological research  •  2000  |  View Paper