Possible Interaction: Linoleic Acid and Vitamin E

“In addition to exhibiting antioxidant properties, conjugated linoleic acid (CLA) and vitamin E may modulate gene expression of endogenous antioxidant enzymes.”

“In conclusion, we found no overall association between serum or dietary alpha-linolenic acid or any other unsaturated fatty acid and prostate cancer risk, but high serum linoleic acid was associated with lower risk in men supplemented with alpha-tocopherol.”

“The rate of the photooxidation of alpha-tocopherol in the presence of linoleic acid was faster than that in the absence of the fatty acid.”

“ Linoleic acid autoxidation inhibitions on all fractions were higher than that on α-tocopherol.”

“In this work, the ability of some ubiquitous dietary antioxidants representative of the main antioxidant classes α-tocopherol , the flavonol quercetin, β-carotene) to inhibit the metmyoglobin-induced peroxidation of linoleic acid is investigated by UV–visible spectroscopy and HPLC in mildly acidic emulsions.”

“Cotreatment of linoleic acid plus quercetin or vitamin E also decreased linoleic acid-induced binding activity of PPARgamma.”

“ Vitamin E treatment increased linoleic acid percent values and decreased myristic acid levels.”

“The amount of linoleic and linolenic acids significantly increased in the vitamin E groups as compared to control group, and were correlated with the liver alpha-tocopherol content.”

“The concentration of vitamin E in liver and plasma was significantly lower in animals fed on the highest concentration of linoleic acid compared with those fed on the lowest level.”

“NE affecting the cerebellum only occurred in the group given linoleic acid and 5 mg alpha-tocopherol/kg.”