Possible Interaction: Linoleic Acid and Stearic Acid

“Replacement of linoleic acid by stearic acid also caused somewhat lower HDL cholesterol and higher LDL cholesterol levels.”

“Linoleic acid LA ) was more inhibitory than oleic acid (OA) and stearic acid ( SA).”

“ Linoleic acid was significantly decreased (P < 0·001) and there was a significant rise (P < 0·05) in its hydrogenation product, stearic acid.”

“In conclusion, our findings indicated that LA elicited inhibitory while SA exerted stimulatory effects on AgRP expression and secretion via TLR4-dependent inflammation and leptin/insulin pathways in N38 cells.”

“Our results demonstrated that LA inhibited, while SA stimulated AgRP expression and secretion of N38 cells in a dose-dependent manner.”

“ Linoleic acid inhibited esterification of palmitic, stearic and oleic acids.”

“Membrane rigidifying agents, such as the saturated fatty acid stearic acid , or the cholesterol derivatives, cholesteryl hemisuccinate and cholesteryl phosphorylcholine, as well as a membrane fluidizing unsaturated fatty acid, linoleic acid , could significantly increase dye uptake, although not as well as verapamil.”

“ Linoleic acid and oleic acid were less potent (IC50 = 130 and 190 microM, respectively), and stearic acid was ineffective.”

“Of the lipid components present, four have been found to affect the accumulation of pancreatic xanthine dehydrogenase: linolenic, linoleic , and oleic acids suppress and stearic acid enhances.”

“Supplementation of the essential fatty acid-deficient diet with linoleic acid caused a rapid loss of eicosatrienoic acid and palmitic acid with a concomitant increase in stearic acid and arachidonic acid.”