Possible Interaction: Linoleic Acid and Quercetin

“ Quercetin also showed a significant negative correlation with linoleic acid (r = −0.49, p < .0001).”

“Surprisingly, quercetin and isorhamnetin afforded a protection to linoleic acid long after their consumption.”

“In the presence of linoleic acid in PBS solution, quercetin inhibited the photooxidation of alpha-TH and alpha-TH stimulated the photooxidation of quercetin.”

“Cotreatment of linoleic acid plus quercetin or vitamin E also decreased linoleic acid-induced binding activity of PPARgamma.”

“ Quercetin reduced linoleic acid-mediated binding activity of NF-kappaB and AP-1 and mRNA levels of inflammatory genes such as interleukin-6 (IL-6) and vascular cell adhesion molecule-1 (VCAM-1).”

“The results suggest that the conjugation of quercetin with linoleic and oleic acids resulted in novel stronger tyrosinase inhibitors which may have therapeutic applications and replacement of toxic tyrosinase inhibitors and contribute as anti- browning agents in food, cosmetic and pharmaceutical industry.”

“On the basis of their chemical structures, we proposed that quercetin reacted with 13-oxo-octadecadienoic acid , 10-oxo-hexadecenoic acid, and 10-oxo-octadecenoic acid formed from peroxidation of linoleic acid, palmitoleic acid, and oleic acid, respectively, to inhibit aldehyde formation.”

“ Quercetin noncompetitively inhibited the peroxidation of linoleic acid catalyzed by soybean lipoxygenase‐1 (EC 1.13.11.12, Type 1) with an IC50 value of 4.8 μM (1.45 μg/ml).”

“Compared to a non-addition group, the optical density of the organic layer that was separated through the addition of chloroform in oxidized linoleic acid significantly and dose-dependently decreased when ginseng extract or quercetin was added.”