Possible Interaction: Linoleic Acid and Polyunsaturated Fatty Acids

“The effect of ALA intake on n-3 LC PUFA was suppressed by LA intake.”

“In the vegetarian group statistically significant coefficients of correlation were demonstrated between the dietary intake of polyunsaturated fatty acids in per cent of calories and the percentages of linoleic acid in the cholesterol esters and triglycerides of serum.”

“ Linoleic acid prevents acute clinical symptoms caused by polyunsaturated fatty acid-deficient diets and is the major precursor for ARA in most human diets.”

“Moreover, the cumulative change in the contribution of LA to total PUFA availability was +7·1 %.”

“RESULTS Among the strongest correlations observed, serum total n-6 PU As an d lin oleic acid we re inversely (max.”

“Dietary total fat, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid PUFA), LA , total &ohgr; 6 polyunsaturated fatty acid (T&ohgr;6PUFA), and &agr;-linolenic acid (ALA) intake positively predicted serum LA concentration.”

“Failure to make a clear distinction among PUFA species may result in inadvertently attributing health effects of n–3 PUFAs to linoleic acid.”

“The main argument was that the biological availability of longer chain PUFA of the n-3 class was compromised by excess linoleic acid and that the cardioprotective advantage of n-3 fatty acids was diminished by linoleic acid.”

“Conjugated linoleic acid (CLA), a naturally occurring anticarcinogen found in dairy products, is an intermediary product of ruminal biohydrogenation of polyunsaturated fatty acids.”

“Evidence from animal studies suggests that conjugated linoleic acid (CLA) modulates plasma and tissue appearance of newly synthesized PUFA.”