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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Linoleic Acid
drug:
Phenobarbital
Research Papers that Mention the Interaction
“ Phenobarbital administration significantly increased the concentrations of palmitic, linoleic , and arachidonic acids in microsomal fractions of chow-fed animals but not in EFAD animals.”
Effects of essential fatty acid deficiency on the induction of liver microsomal membranes by phenobarbital: an ultrastructural and biochemical investigation.“In phosphatidylethanolamine fractions, phenobarbital increased palmitoleic, oleic, linoleic , and arachidonic acids; carbon tetrachloride elicited opposite effects on these acids.”
“ Phenobarbitone caused the proportion of linoleic acid in phosphatidylcholine and phosphatidylethanolamine to increase to 120-125% of the control and the proportion of oleic acid, arachidonic acid and docosahexaenoic acid to decrease.”
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