Possible Interaction: Linoleic Acid and Palmitic Acid

“Increasing dietary intake of linoleic acid decreased plasma triacylglycerol level when subjects consumed a low level of dietary palmitic acid.”

“Replacement of palmitic acid by linoleic acid in the incubation medium resulted in a decrease of the glycerol incorporation rate into phosphoglycerides.”

“Co-treatment of PA with LA , OA, and DHA significantly inhibited FA uptake in PA-treated cells.”

“Furthermore, we observed that linoleic acid effectively reversed the inflammatory responses induced by palmitic acid treatment in microglial cells.”

“ Linoleic acid inhibited esterification of palmitic , stearic and oleic acids.”

“Addition of palmitic acid to the incubation medium stimulated synthesis and incorporation of fatty acids synthesized de novo into triacylglycerols, whereas stearic and linoleic acid were inhibitory.”

“ Palmitic acid stimulated renin activity versus synthetic tetradecapeptide renin substrate about 7-fold in this buffer, with half-maximal stimulation at 14 microM. Stearic and myristic acids also showed good stimulation but linoleic acid and ethyl myristate were much less effective at the stimulation.”

“Other fatty acids including oleic, arachidonic, and palmitic only partially substitute for the growth-promoting effect of linoleic acid.”

“The infusion of free linoleic acid into the rumen of sheep resulted in an increase in the proportion of total 18:1 and a decrease in the proportions of 16:0 and 18:0 in the total rumen free fatty acids.”

“Progeny showed extensive variation in fat levels and composition, with the level of palmitic acid negatively correlated to the sum of stearic acid, oleic acid, and linoleic acid.”