Possible Interaction: Linoleic Acid and Oleic Acid

“Together with the ANS-binding spectra, which exhibited a blue-shift (from 516.20 to 514.10 … and 508.50 nm, respectively) with an increased fluorescence intensity, it can be indicated that binding of oleic acid … linoleic acid lead to the exposure of hydrophobic amino acids and hydrophobic regions.”

“A significant inverse association between oleic and linoleic FA intake and SGT was recorded.”

“An inhibitory effect attributed to an increased intake of oleic acid could be due to an inadequate supply of linoleic acid.”

“Kinetic assays demonstrated that oleic acid and linoleic acid were competitive inhibitors, and their interactions with α-glucosidase exhibited a character of static quenching, which indicates that they would bind to α-glucosidase to form a complex.”

“Taken together, these results conclude that oleic acid and linoleic acid possess potent inhibitory effects on α-glucosidase activity.”

“ Oleic and linoleic acid were inversely correlated (r=-0.99, P= 0.05) and together accounted for 91.16% to 94.29% of the total soluble lipids.”

“This flux may in the fetus augment de novo synthesis of fatty acids, which not only dilutes transplacentally transported EFA/LCP, but also causes competition of de novo synthesized oleic acid with linoleic acid for delta-6 desaturation.”

“In all the age groups there was an inverse relationship between linoleic acid and oleic acid , and between palmitic acid and stearic acid.”

“Propionate degradation was unaffected by the presence of SA; however, elevated levels and longer removal times were observed in cultures receiving LA and OA.”

“Noteworthy, linoleic acid prohibited the protective action of oleic acid non-competitively.”

“Whereas increasing the concentration of linoleic acid by itself greatly diminished the growth of all 11 strains, concomitant increases in oleic acid greatly diminished the inhibitory effect of linoleic acid.”