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Last Updated: 2 years ago

Possible Interaction: Linoleic Acid and Nitric Oxide

Research Papers that Mention the Interaction

No ' protective' effect of linoleic , linolenic or eicosapentaenoic acid was demonstrable.
The Canadian journal of cardiology  •  1995  |  View Paper
In BV-2 mouse microglia activated with lipopolysaccharide (LPS), exposure to LA reduced NO secretion and inducible nitric oxide synthase (iNOS) levels, whereas exposure to ALA reduced NO without a corresponding reduction of iNOS.
Molecular and Cellular Neuroscience  •  2020  |  View Paper
Linoleic acid reduced nitric oxide production and down regulated the expression of neuroinflammatory iNOS and COX2 genes in BV2 cells.
Natural product communications  •  2016  |  View Paper
This leads to the conclusion that linoleic acid from A. brasiliensis could reduce NO production and inflammatory activity in RAW 264.7 cells by the inhibition of p50 and via the activation of PPARα.
This study found that linoleic acid isolated from A. brasiliensis inhibited NO production and suppressed the expression of pro-inflammatory cytokines including TNF-α, IL-6, IL-1β, and NOS2 in RAW 264.7 cells.
Food & function  •  2017  |  View Paper
Only LA increased the cellular nitric oxide levels in a calcium-dependent manner.
BMC Veterinary Research  •  2016  |  View Paper
However, effect of LA on EDRF production remains controversial.
LA at 0.1-5 μmol/L attenuated bradykinin (BK)-induced NO and PGI2 production while suppressing the BK-induced Ca(2+) response dose-dependently.
Circulation journal : official journal of the Japanese Circulation Society  •  2013  |  View Paper
LA exposure increased intracellular calcium, nitric oxide , and tetrahydrodiopterin levels as well as the expression of E-selectin.
Journal of lipid research  •  2004  |  View Paper
NO reduced the O2 consumption during the radical initiator-induced oxidation of linoleic acid in an aqueous medium.
Chemical & pharmaceutical bulletin  •  2003  |  View Paper
The results showed that the treatment with 10 microL/L NO significantly increased the contents of the palmitoleic (16:1), oleic (18:1), and linolenic (18:3) acid in phospholipid (PL), while it decreased the contents of linoleic (18:2) acid in PL.
Journal of agricultural and food chemistry  •  2006  |  View Paper
Incubation of J774.2 cells with linoleic acid significantly increased TNFα and nitric oxide production; arachidonic acid enhanced TNFα production but reduced nitric oxide production.
Mediators of inflammation  •  1995  |  View Paper
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