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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Linoleic Acid
supplement:
Masoprocol
Research Papers that Mention the Interaction
“Although NDGA was more inhibitory of cell growth in the presence of LA or CLA than INDO, growth was associated with both prostaglandin and leukotriene production.”
Proliferative responses of normal human mammary and MCF-7 breast cancer cells to linoleic acid, conjugated linoleic acid and eicosanoid synthesis inhibitors in culture.“ Nordihydroguaiaretic acid and high concentrations of indomethacin, each of which inhibits the lipoxygenase pathway of arachidonate metabolism, were effective in reversing the stimulatory effect of LA on MDA-MB-231 cell adhesion.”
“The inhibition by NDGA was reversed by arachidonic, linoleic , and oleic acids.”
Multiple Contributions from Long‐Chain Fatty Acid Metabolism in Y‐1 and MA‐10 Cells“Furthermore, nordihydroguaiaretic acid , a potent inhibitor of the lipoxygenase system, significantly reduced the growth-response effects of linoleic acid in VSMC, suggesting that conversion of linoleic acid to hydroperoxyoctadecadienoic acids (HPODEs) is required for these effects.”
“ Nordihydroguaiaretic acid (80 microM) and alpha-tocopherol (100 microM) significantly decreased the cell death observed during incubations with AA or LA.”
“Incubation of soybean lipoxygenase and linoleic acid with p-aminophenol, catechol, hydroquinone, NDGA , or phenidone resulted in the formation of the one-electron oxidation products of these compounds.”
Formation of free radical metabolites in the reaction between soybean lipoxygenase and its inhibitors. An ESR study.
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