Possible Interaction: Linoleic Acid and Linolenic Acid

“Compared to our previous study, where we simply increased the ALA intake, our results show that ALA supplementation combined with a reduced LA intake (loLA/hiALA diet) more efficiently enhanced EPA blood concentrations.”

“Conclusions: In a CHD high-risk population with LA-rich background diet, these cross-sectional data suggest that replacing LA in the diet by ALA may decrease diastolic blood pressure, and may increase serum triacylglycerol concentration.”

“ ALA and its mixture with linoleic acid can prolong the hemorrhage and coagulation time as well as enhanced the survival rate of mice subjected to collagen-adrenaline induced thrombosis.”

“In addition to its own direct preventive effect on cardiac arrhythmias, dietary ALA actually inhibits the elongation and desaturation of linoleic acid (18:2 n-6) into arachidonic acid.”

“The ratio of LA to LNA , (21.6), was higher than has been reported from other countries.”

“The small amount of alpha-linolenic acid present in cows' milk may however exert a sparing effect on linoleic acid.”

“2) High intakes of LA competitively interfere with the endogenous conversion of alpha-linolenic acid (ALA) to EPA and DHA. (”

“The actions of LA and ALA may be divergent and interdependent.”

“Dietary total fat, monounsaturated fatty acid (MUFA), polyunsaturated fatty acid (PUFA), LA , total &ohgr; 6 polyunsaturated fatty acid (T&ohgr;6PUFA), and &agr;-linolenic acid ( ALA ) intake positively predicted serum LA concentration.”

“High LA levels, as found for instance in sunflower, safflower, corn, peanut and soy oils, may inhibit the conversion of ALA into its LC-PUFA derivatives.”