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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Linoleic Acid
drug:
Leptin
Research Papers that Mention the Interaction
“Also, dietary supplements, such as linoleic acid , zinc, vitamin A, vitamin D, vitamin E, and -3 fatty acid, could affect plasma leptin levels (7,8).”
Effect of Leptin on the Relationship Between Body Weight and Knee Osteoarthritis—a Methodologic Approach: Comment on the Article by Fowler‐Brown et al“Maternal lipids and leptin were altered following elevated linoleic acid consumption.”
Elevated maternal linoleic acid reduces circulating leptin concentrations, cholesterol levels and male fetal survival in a rat model“ Linoleic acid (1–200 μM) significantly decreased insulin-stimulated leptin secretion and expression (P < 0.05), however, no changes in basal leptin production were observed.”
“Long-chain mono- and polyunsaturated fatty acids constitutively present in adipocyte triglyceride stores (oleic, linoleic , gamma-linolenic, palmitoleic, eicosapentanoic, and docosahexanoic acids) also completely suppressed leptin secretion.”
“Feature ratios of several fatty acids-myristic acid [m/z 227.2018, … (RT) 229], heptadecanoic acid (m/z 269.2491, RT 276), linoleic acid (m/z 280.2358, RT 236)-… correlated with fasting plasma concentrations of leptin (nanograms per milliliter) and adiponectin (micrograms … milliliter), respectively (all P < 0.05).”
Metabolomic Profiling Demonstrates Postprandial Changes in Fatty Acids and Glycerophospholipids Are Associated with Fasting Inflammation in Guatemalan Adults.
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