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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Linoleic Acid
supplement:
Gamma-Linolenic Acid
Research Papers that Mention the Interaction
“Correlation of individual LA and GLA values showed significantly steeper regression lines in low-IgE responders (B and D, kx = 0.058) than in high-IgE responders (A and C, kx = 0.012; p < 0.02), suggesting impaired delta-6-desaturase function in the latter.”
Plasma levels of polyunsaturated fatty acids in children with atopic dermatitis and in atopic and nonatopic controls“Whereas a high intake of n-6 PUFA and saturated fat has tumor-enhancing effects, n-3 PUFA, conjugated linoleic acid and gamma-linolenic acid have inhibitory effects.”
“Consequently, the results support the hypothesis that the oxidative desaturation of linoleic acid to γ-linolenic acid is the main controllable step in the biosynthesis of polyunsaturated fatty acids of the linoleic acid family in the microsomes.”
Comparative effect of glucagon, dibutyryl cyclic AMP, and epinephrine on the desaturation and elongation of linoleic acid by rat liver microsomes“ LA and GLA were found to be equipotent in inhibiting growth of the in vitro cultured BL6 cells which were found to contain an appreciable level of delta-6-desaturase activity.”
“5) When the concentration ratio of [1- 14 C]linoleic acid to microsomal protein was increased so that the desaturating enzyme was the limiting factor, cis -linoleic, trans -linoleic and γ-linolenic acids all inhibited linoleic acid desaturation.”
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